archetype (adl_version=1.4; uid=677a2484-3ebd-49c9-81fc-b8341fae7a33) openEHR-EHR-OBSERVATION.hscore.v0 concept [at0000] -- HScore language original_language = <[ISO_639-1::en]> translations = < ["nb"] = < language = <[ISO_639-1::nb]> author = < ["name"] = <"Marit Alice Venheim"> ["organisation"] = <"Helse Vest IKT"> ["email"] = <"marit.alice.venheim@helse-vest-ikt.no"> > > > description original_author = < ["name"] = <"Liv Laugen"> ["organisation"] = <"Oslo universitetssykehus"> ["email"] = <"liv.laugen@ous-hf.no"> ["date"] = <"2020-03-30"> > details = < ["nb"] = < language = <[ISO_639-1::nb]> purpose = <"For å registrere et estimat av ett individs risiko for å ha sekundær hemofagocytisk lymfohistiocytose."> use = <"Brukes for å registrere et estimat av ett individs risiko for å ha sekundær hemofagocytisk lymfohistiocytose."> keywords = <"HLH, sHLH, sekundær Hemofagisk lymfohistocytose, COVID-19, infeksjon, Reaktiv Heomfagocytisksyndrom, RAS, Makrofag Aktiveringsyndrom, MAS, Sekundær/reaktiv HLH", ...> misuse = <""> > ["en"] = < language = <[ISO_639-1::en]> purpose = <"To record an estimation of an individual's risk of having reactive hemophagocytic syndrome."> use = <"Use to record an estimation of an individual's risk of having reactive hemophagocytic syndrome."> keywords = <"HLH, Hemophagocytic lymphohistiocytosis, COVID-19, infection,", ...> misuse = <""> > > lifecycle_state = <"in_development"> other_contributors = <"Heather Leslie, Atomica Informatics, Australia (openEHR Editor)", "Vebjørn Arntzen, Oslo university hospital, Norway", "Silje Ljosland Bakke, Helse Vest IKT AS, Norway", "Marit Alice Venheim, Helse Vest IKT AS, Norway"> other_details = < ["licence"] = <"This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/."> ["custodian_organisation"] = <"openEHR Foundation"> ["references"] = <"Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P, Hejblum G. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690. PubMed PMID: 24782338. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 Mar 16;. doi: 10.1016/S0140-6736(20)30628-0. [Epub ahead of print] PubMed PMID: 32192578. "> ["original_namespace"] = <"org.openehr"> ["original_publisher"] = <"openEHR Foundation"> ["custodian_namespace"] = <"org.openehr"> ["MD5-CAM-1.0.1"] = <"2F7A9970BE5A959CEFD5211DB1907494"> ["build_uid"] = <"b0a5f2b4-f7a1-43fd-ac35-a3a392df19f8"> ["revision"] = <"0.0.1-alpha"> > definition OBSERVATION[at0000] matches { -- HScore data matches { HISTORY[at0001] matches { -- History events cardinality matches {0..*; unordered} matches { EVENT[at0002] occurrences matches {0..*} matches { -- Any event data matches { ITEM_TREE[at0003] matches { -- Tree items cardinality matches {0..*; unordered} matches { ELEMENT[at0004] occurrences matches {0..1} matches { -- Temperature value matches { 0|[local::at0005], 33|[local::at0006], 49|[local::at0007] } } ELEMENT[at0008] occurrences matches {0..1} matches { -- Organomegaly value matches { 0|[local::at0009], 23|[local::at0010], 38|[local::at0011] } } ELEMENT[at0012] occurrences matches {0..1} matches { -- Number of cytopenias value matches { 0|[local::at0013], 24|[local::at0014], 34|[local::at0015] } } ELEMENT[at0016] occurrences matches {0..1} matches { -- Triglycerides value matches { 0|[local::at0024], 44|[local::at0025], 64|[local::at0026] } } ELEMENT[at0017] occurrences matches {0..1} matches { -- Fibrinogen value matches { 0|[local::at0027], 30|[local::at0028] } } ELEMENT[at0018] occurrences matches {0..1} matches { -- Ferritin value matches { 0|[local::at0029], 35|[local::at0030], 50|[local::at0031] } } ELEMENT[at0019] occurrences matches {0..1} matches { -- Aspartate aminotransferase value matches { 0|[local::at0032], 19|[local::at0033] } } ELEMENT[at0020] occurrences matches {0..1} matches { -- Haemophagocytosis on bone marrow aspirate value matches { 0|[local::at0034], 35|[local::at0035] } } ELEMENT[at0021] occurrences matches {0..1} matches { -- Known immunosuppression value matches { 0|[local::at0022], 18|[local::at0023] } } ELEMENT[at0036] occurrences matches {0..1} matches { -- Total HScore value matches { DV_COUNT matches { magnitude matches {|0..337|} } } } ELEMENT[at0037] occurrences matches {0..1} matches { -- Probability of HS value matches { DV_PROPORTION matches { numerator matches {|0.0..100.0|} type matches {2} } } } } } } } } } } protocol matches { ITEM_TREE[at0038] matches { -- Item tree items cardinality matches {0..*; unordered} matches { allow_archetype CLUSTER[at0039] occurrences matches {0..*} matches { -- Extension include archetype_id/value matches {/.*/} } } } } } ontology term_definitions = < ["en"] = < items = < ["at0000"] = < text = <"HScore"> description = <"Estimate an individual's risk of having reactive hemophagocytic syndrome. "> > ["at0001"] = < text = <"History"> description = <"@ internal @"> > ["at0002"] = < text = <"Any event"> description = <"Default, unspecified point in time or interval event which may be explicitly defined in a template or at run-time."> > ["at0003"] = < text = <"Tree"> description = <"@ internal @"> > ["at0004"] = < text = <"Temperature"> description = <"Range category for the body temperature measurement."> > ["at0005"] = < text = <"<38.4°C"> description = <"The body temperature of the individual is less than 38.4°C."> > ["at0006"] = < text = <"38.4-39.4°C"> description = <"The body temperature of the individual is between 38.4 and 39.4°C."> > ["at0007"] = < text = <">39.4°C"> description = <"The body temperature of the individual is greater than 39.4°C."> > ["at0008"] = < text = <"Organomegaly"> description = <"Findings of any enlargement of the liver or/and spleen in the individual."> > ["at0009"] = < text = <"None"> description = <"No enlargement of the liver or the spleen."> > ["at0010"] = < text = <"Hepatomegaly or splenomegaly"> description = <"Enlargment of the liver or the spleen."> > ["at0011"] = < text = <"Hepatomegaly and splenomegaly"> description = <"Enlargement of both the liver and the spleen."> > ["at0012"] = < text = <"Number of cytopenias"> description = <"Number of cytopenias present - in red cells, white cells and/or platelets."> comment = <"Defined as either haemoglobin concentration of 9.2 g/dL or less (≤5.71 mmol/L), a white blood cell count of 5000 white blood cells per mm³ (5,0 x 10E9/L) or less, or platelet count of 110 000 platelets per mm³ (110 x 10E9/L) or less, or all of these criteria combined. "> > ["at0013"] = < text = <"One lineage"> description = <"Cytopenia in only one cell lineage."> > ["at0014"] = < text = <"Two lineages"> description = <"Cytopenia in two cell lineages."> > ["at0015"] = < text = <"Three lineages"> description = <"Cytopenia in three cell lineages."> > ["at0016"] = < text = <"Triglycerides"> description = <"The triglycerides category, measured in mmol/L or mg/dL."> > ["at0017"] = < text = <"Fibrinogen"> description = <"The fibrinogen category, measured in g/L or mg/dL."> > ["at0018"] = < text = <"Ferritin"> description = <"The ferritin category, measured in ng/mL or μg/L."> > ["at0019"] = < text = <"Aspartate aminotransferase"> description = <"An individvals serum aspartate aminotransferase level measured in U/L."> comment = <"This is also known as AST, AspAT, ASAT, AAT or SGOT."> > ["at0020"] = < text = <"Haemophagocytosis on bone marrow aspirate"> description = <"Presence of hemophagocytosis features in bone marrow aspirate."> > ["at0021"] = < text = <"Known immunosuppression"> description = <"Presence of known underlying immunosuppression."> comment = <"For example HIV positive or receiving long-term immunosuppressive therapy."> > ["at0022"] = < text = <"No"> description = <"No known underlying immunosuppression."> > ["at0023"] = < text = <"Yes"> description = <"Known underlying immunosuppression."> > ["at0024"] = < text = <"<1.5 mmol/L"> description = <"The Triglyceride level is less than 1.5 mmol/L or 132.7 mg/dL."> > ["at0025"] = < text = <"1.5-4.0 mmol/L"> description = <"The Triglyceride level is 1.5-4.0 mmol/L or 132.7-354 mg/dL."> > ["at0026"] = < text = <">4.0 mmol/L"> description = <"The Triglyceride level is greater than 4.0 mmol/L or 354 mg/dL."> > ["at0027"] = < text = <">2.5 g/L"> description = <"The fibinogen level is greater than 2.5 g/L or 250 mg/dL."> > ["at0028"] = < text = <"≤2.5 g/L"> description = <"The fibinogen level is less than or equal to 2.5 g/L 250 mg/dL."> > ["at0029"] = < text = <"<2000 ng/ml"> description = <"The ferritin level is less than 2000 ng/ml or 2000 μg/L."> > ["at0030"] = < text = <"2000–6000 ng/ml"> description = <"The ferritin level is 2000-6000 ng/ml or 2000-6000 μg/L."> > ["at0031"] = < text = <">6000 ng/ml"> description = <"The ferritin level is greater than 6000 ng/ml or 6000 μg/L."> > ["at0032"] = < text = <"<30 U/L"> description = <"The aspartate aminotransferase level is less than 30 U/L."> > ["at0033"] = < text = <"≥30 U/L"> description = <"The aspartate aminotransferase level is greater than or equal to 30 U/L."> > ["at0034"] = < text = <"No"> description = <"No hemophagocytosis features are present in bone marrow aspirate."> > ["at0035"] = < text = <"Yes"> description = <"Hemophagocytosis features are present in bone marrow aspirate."> > ["at0036"] = < text = <"Total HScore"> description = <"The total sum for each component variable for the HScore."> > ["at0037"] = < text = <"Probability of HS"> description = <"Probability of an individual having reactive hemophagocytic syndrome."> comment = <"According to table 5 in the original original paper by Fardet et al, https://doi.org/10.1002/art.38690."> > ["at0038"] = < text = <"Item tree"> description = <"@ internal @"> > ["at0039"] = < text = <"Extension"> description = <"Additional information required to extend the model with local content or to align with other reference models or formalisms. "> comment = <"For example: local information requirements; or additional metadata to align with FHIR."> > > > ["nb"] = < items = < ["at0000"] = < text = <"HScore"> description = <"Estimerer ett individs risiko for å ha sekundær hemofagocytisk lymfohistiocytose."> > ["at0001"] = < text = <"History"> description = <"@ internal @"> > ["at0002"] = < text = <"Uspesifisert hendelse"> description = <"Standard, uspesifisert tidspunkt eller tidsintervall som kan defineres mer eksplisitt i et templat eller i en applikasjon."> > ["at0003"] = < text = <"Tree"> description = <"@ internal @"> > ["at0004"] = < text = <"Tempratur"> description = <"Måling av kroppstemperatur."> > ["at0005"] = < text = <"<38,4°C"> description = <"Kroppstemperaturen til individet er mindre enn 38,4°C."> > ["at0006"] = < text = <"38,4-39,4°C"> description = <"Kroppstemperaturen til individet er mellom 38,4 og 39,4°C."> > ["at0007"] = < text = <">39.4°C"> description = <"Kroppstemperaturen til individet er større enn 39,4°C."> > ["at0008"] = < text = <"Organomegali"> description = <"Funn av forstørret lever og/eller milt hos individet."> > ["at0009"] = < text = <"Ingen"> description = <"Ingen forstørret lever og/eller milt hos individet."> > ["at0010"] = < text = <"Hepatomegali eller splenomegali"> description = <"Forstørret lever eller milt."> > ["at0011"] = < text = <"Hepatomegali og splenomegali"> description = <"Forstørret lever og milt."> > ["at0012"] = < text = <"Antall cytopenier"> description = <"Antall cytopenier til stede - i den røde cellelinjen, hvite cellelinjen og/eller blodplatelinjen."> comment = <"Definert som enten hemoglobinkonsentrasjon på 9,2 g/dL eller mindre (≤5,71 mmol/L), et antall hvite blodlegemer på 5000 hvite blodlegemer per mm³ (5,0 x 10E9/L) eller mindre, eller antall blodplater på 110 000 blodplater per mm³ (110 x 10E9/L) eller mindre, eller alle disse kriteriene kombinert."> > ["at0013"] = < text = <"En linje"> description = <"Cytopeni i kun en cellelinje."> > ["at0014"] = < text = <"To linjer"> description = <"Cytopeni i to cellelinjer."> > ["at0015"] = < text = <"Tre linjer"> description = <"Cytopeni i tre cellelinjer."> > ["at0016"] = < text = <"Triglyserider"> description = <"Triglyseridkonsentrasjonen målt i mmol/L eller mg/dL."> > ["at0017"] = < text = <"Fibrinogen"> description = <"Fibrinogenkonsentrasjonen målt i g/L eller mg/dL."> > ["at0018"] = < text = <"Ferritin"> description = <"Ferritinkonsentrasjonen mål i ng/mL or μg/L."> > ["at0019"] = < text = <"Aspartataminotransferase"> description = <"Ett individs aspartataminotransferasekonsentrasjon målt i U/L."> comment = <"Dette er også kjent som AST, AspAT, ASAT, AAT eller SGOT."> > ["at0020"] = < text = <"Hemofagocytose i benmargsaspirat"> description = <"Funn av fagocytose i benmargsaspiratet."> > ["at0021"] = < text = <"Kjent immunsuppresjon"> description = <"Tilstedeværelse av kjent immunsuppresjon."> comment = <"For eksempel HIV-positiv eller pågående langvarig immunsuppressiv behandling."> > ["at0022"] = < text = <"Nei"> description = <"Ingen kjent immunsuppresjon."> > ["at0023"] = < text = <"Ja"> description = <"Kjent immunsuppresjon."> > ["at0024"] = < text = <"<1,5 mmol/L"> description = <"Triglyseridkonsentrasjonen er mindre enn 1,5 mmol/L eller 132,7 mg/dL."> > ["at0025"] = < text = <"1,5-4,0 mmol/L"> description = <"Triglyseridkonsentrasjonen er 1,5-4,0 mmol/L eller 132,7-354 mg/dL."> > ["at0026"] = < text = <">4,0 mmol/L"> description = <"Triglyseridkonsentrasjonen er større enn 4,0 mmol/L eller 354 mg/dL."> > ["at0027"] = < text = <">2,5 g/L"> description = <"Fibrinogenkonsentrasjonen er større enn 2,5 g/L eller 250 mg/dL."> > ["at0028"] = < text = <"≤2,5 g/L"> description = <"Fibrinogenkonsentrasjonen er mindre enn eller er lik 2,5 g/L eller 250 mg/dL."> > ["at0029"] = < text = <"<2000 ng/ml"> description = <"Ferritinkonsentrasjonen er mindre enn 2000 ng/ml eller 2000 μg/L."> > ["at0030"] = < text = <"2000–6000 ng/ml"> description = <"Ferritinkonsentrasjonen er 2000-6000 ng/ml eller 2000-6000 μg/L."> > ["at0031"] = < text = <">6000 ng/ml"> description = <"Ferritin nivået er større enn 6000 ng/ml eller 6000 μg/L."> > ["at0032"] = < text = <"<30 U/L"> description = <"Aspartataminotransferasekonsentrasjonen er mindre enn 30 U/L."> > ["at0033"] = < text = <"≥30 U/L"> description = <"Aspartataminotransferasekonsentrasjonen er mer enn eller er lik 30 U/L."> > ["at0034"] = < text = <"Nei"> description = <"Det er ikke funnet hemofagocytose i benmargsaspiratet."> > ["at0035"] = < text = <"Ja"> description = <"Det er funnet hemofagocytose i benmargsaspiratet."> > ["at0036"] = < text = <"Total HScore"> description = <"Summen av skår av hver enkelt kategori."> > ["at0037"] = < text = <"Sannsynligheten for sekundær HLH"> description = <"Sannsynligheten for at ett individ har sekundær hemofagocytisk lymfohistiocytose."> comment = <"I følge tabell 5 i originalstudien av Fardet et al, https://doi.org/10.1002/art.38690."> > ["at0038"] = < text = <"Item tree"> description = <"@ internal @"> > ["at0039"] = < text = <"Tilleggsinformasjon"> description = <"Ytterligere informasjon som trengs for å kunne registrere lokalt definert innhold eller for å tilpasse til andre referansemodeller/formalismer."> comment = <"For eksempel lokale informasjonsbehov eller ytterligere metadata for å kunne tilpasse til tilsvarende konsepter i FHIR eller CIMI."> > > > >